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Friday, April 26, 2013

Article of Interest: Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX)

This randomized control trial published in the "Online First" section of Journal of the American Medical Association: Internal Medicine (JAMA Intern Med) looks at the effects of long-term intensive exercise on home-dwelling patients with Alzheimer's Disease.

To see whether exercise is beneficial for AD patients please see the abstract below, or click through to the article.

Pitkala, K.H. et. al. (2013). Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX). JAMA INTERN MED. epub version.  Accessed online


Importance: Few rigorous clinical trials have investigated the effectiveness of exercise on the physical functioning of patients with Alzheimer disease (AD)

Objectives: To investigate the effects of intense and long-term exercise on the physical functioning and mobility of home-dwelling patients with AD and to explore its effects on the use and costs of health and social services.

Design: A randomized controlled trial. Setting and Participants: A total of 210 home-dwelling patients with AD living with their spousal caregiver. Interventions: The 3 trial arms included (1) group-based exercise (GE; 4-hour sessions with approximately 1-hour training) and (2) tailored home-based exercise (HE; 1-hour training), both twice a week for 1 year, and (3) a control group (CG) receiving the usual community care.

Main Outcome: Measures The Functional Independence Measure (FIM), the Short Physical Performance Battery, and information on the use and costs of social and health care services. Results: All groups deteriorated in functioning during the year after randomization, but deterioration was significantly faster in the CG than in the HE or GE group at 6 months. The FIM changes at 12 months were −7.1 (95% CI, −3.7 to −10.5), −10.3 (95% CI, −6.7 to −13.9), and −14.4 (95% CI, −10.9 to −18.0) in the HE group, GE group, and CG, respectively. The HE and GE groups had significantly fewer falls than the CG during the follow-up year. The total costs of health and social services for the HE patient-caregiver dyads (in US dollars per dyad per year) were $25 112 (95% CI, $17 642 to $32 581) (P=.13 for comparison with the CG), $22 066 in the GE group ($15 931 to $28 199; P=.03 vs CG), and $34 121 ($24 559 to $43 681) in the CG.

Conclusions and Relevance: An intensive and long-term exercise program had beneficial effects on the physical functioning of patients with AD without increasing the total costs of health and social services or causing any significant adverse effects.

Trial Registration: Identifier: ACTRN12608000037303

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